Imaging space weather over Europe

[1] We describe the introduction of the first all-sky imaging system for low-light-level optical observations of the disturbed ionosphere over mid-latitude Europe. Using 6300 angstrom auroral emissions that come from the 200-400 km altitude range, we demonstrate that sub-visual optical patterns spanning the European continent can be obtained from a single site in Italy. Pilot observations during the 26-27 September 2011 geomagnetic storm show that the diffuse aurora's low latitude boundary can be used to find where the poleward wall of the ionospheric trough is located. This relates directly to regions of radiowave disruptions caused by the precipitation of energetic particles from the magnetospheric plasma sheet that move to lower latitudes during space weather events. Images of stable auroral red (SAR) arcs can be used to track the magnetospheric ring current and plasmapause location, a second region of radiowave interference. Comparisons with ground-based and satellite observations of the ionosphere during the same storm demonstrate how ASI images reveal the lowest energy components of magnetospheric input to the ionosphere-thermosphere system. Such observations can be used, potentially, for both now-casting of storm effects spanning Europe, and for retrospective validation of existing models of space weather impacts at sub-auroral locations. Citation: Baumgardner, J., et al. (2013), Imaging space weather over Europe, Space Weather, 11, 69-78, doi:10.1002/swe.20027

Intracranial high-γ connectivity distinguishes wakefulness from sleep.

Neural synchrony in the γ-band is considered a fundamental process in cortical computation and communication and it has also been proposed as a crucial correlate of consciousness. However, the latter claim remains inconclusive, mainly due to methodological limitations, such as the spectral constraints of scalp-level electroencephalographic recordings or volume-conduction confounds. Here, we circumvented these caveats by comparing γ-band connectivity between two global states of consciousness via intracranial electroencephalography (iEEG), which provides the most reliable measurements of high-frequency activity in the human brain. Non-REM Sleep recordings were compared to passive-wakefulness recordings of the same duration in three subjects with surgically implanted electrodes. Signals were analyzed through the weighted Phase Lag Index connectivity measure and relevant graph theory metrics. We found that connectivity in the high-γ range (90-120 Hz), as well as relevant graph theory properties, were higher during wakefulness than during sleep and discriminated between conditions better than any other canonical frequency band. Our results constitute the first report of iEEG differences between wakefulness and sleep in the high-γ range at both local and distant sites, highlighting the utility of this technique in the search for the neural correlates of global states of consciousness

new pre clinical evidence of anti inflammatory effect and safety of a substituted fluorophenyl imidazole

Abstract Acute Respiratory Distress Syndrome (ARDS) is an inflammatory condition with high mortality rates, and there is still no pharmacological approach with proven effectiveness. In the past few years, several imidazole small molecules have been developed to treat conditions in which inflammation plays a central role. In the present work, we hypothesize that a novel substituted fluorophenyl imidazole synthetized by our research group would present in vivo anti-inflammatory effect in an ARDS murine model induced by LPS. Results shows that the fluorophenyl imidazole has the ability to inhibit leukocyte migration to the bronchoalveolar lavage fluid and lung tissue of animals challenged intranasally with LPS. Furthermore, this inhibition is followed with reduction in myeloperoxidase activity, nitric oxide metabolites generation and cytokines (TNF-α, IL-6, IL-17, IFN-γ and IL-10) secretion. This effect is at least partly related to the capacity of the fluorophenyl imidazole in inhibit p38 MAPK and NF-κB phosphorylation. Finally, fluorophenyl imidazole showed no signs of acute oral toxicity in the toxicological protocol suggested by OECD 423. Taken together, the results shows that fluorophenyl imidazole is a promising prototype for the development of a novel anti-inflammatory drug in which p38 MAPK and NF-κB plays a pivotal role

Early detection of intentional harm in the human amygdala

A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.Fil: Hesse Rizzi, Eugenia Fátima. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mikulan, Ezequiel Pablo. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Decety, Jean. University of Chicago; Estados UnidosFil: Sigman, Mariano. Universidad de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Del Carmen Garcia, María. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Silva, Walter. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Ciraolo, Carlos. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Vaucheret, Esteban. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Baglivo, Fabricio. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; ChileFil: Manes, Facundo Francisco. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Ibañez, Agustin Mariano. Universidad Diego Portales; Chile. Universidad Autonoma del Caribe; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentin

Time to Face Language: Embodied Mechanisms Underpin the Inception of Face-Related Meanings in the Human Brain

In construing meaning, the brain recruits multimodal (conceptual) systems and embodied (modality-specific) mechanisms. Yet, no consensus exists on how crucial the latter are for the inception of semantic distinctions. To address this issue, we combined electroencephalographic (EEG) and intracranial EEG (iEEG) to examine when nouns denoting facial body parts (FBPs) and nonFBPs are discriminated in face-processing and multimodal networks. First, FBP words increased N170 amplitude (a hallmark of early facial processing). Second, they triggered fast (~100 ms) activity boosts within the face-processing network, alongside later (~275 ms) effects in multimodal circuits. Third, iEEG recordings from face-processing hubs allowed decoding ~80% of items before 200 ms, while classification based on multimodal-network activity only surpassed ~70% after 250 ms. Finally, EEG and iEEG connectivity between both networks proved greater in early (0-200 ms) than later (200-400 ms) windows. Collectively, our findings indicate that, at least for some lexico-semantic categories, meaning is construed through fast reenactments of modality-specific experience.Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Universidad de San Andrés; Argentina. Universidad de Santiago de Chile; Chile. University of California; Estados UnidosFil: Hesse Rizzi, Eugenia Fátima. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Università degli Studi di Milano; ItaliaFil: Martorell Caro, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; ArgentinaFil: Bekinchstein, Tristán. University of Cambridge; Reino UnidoFil: García, María del Carmen. Hospital Italiano; ArgentinaFil: Silva, Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; ArgentinaFil: Ciraolo, Carlos. Hospital Italiano; ArgentinaFil: Vaucheret Paz, Esteban Fabian. Hospital Italiano; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; ArgentinaFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chil

Edge turbulence in ISTTOK : a multi-code fluid validation

Fluid models used to study the edge plasma region need to be benchmarked against similar conditions given that models can strongly differ in complexity and therefore the results they produce. Via this validation study undertaken through the framework of EUROfusion Enabling Research, four state-of-the art models - GBS, Hermes/BOUT++, HESEL and TOKAM3X - are compared to experimental plasma turbulence measurements on the ISTTOK tokamak. Statistical comparisons of simulation and experiment data show that fluid models used here can replicate most of the experiment in terms of $I_{sat}$ and $V_{float}$ fluctuations. Furthermore, it is shown that without including more complex information (like core turbulence information and domain geometry details and magnetic topological aspects) in fluid models, the results recovered can fall short from the experimental results. Via the simulations using these codes, it is demonstrated that fluid models continue to be a good cost-effective tool in recovering many global aspects of edge plasma behaviour

Obra "Ubú forever"

Esta obra forma parte del Proyecto de Producción CePIAbierto 2017 (RHCD FA N° 89/2017) "Ubú y la rebelión de la forma". Este proyecto se define como un proceso de producción escénica que indaga en la reescritura libre de la saga Ubuesca de Alfred Jarry: Ubú Rey (1896), Ubú Encadenado y Ubú Cornudo (1900). "En esta investigación escénica trabajamos sobre la forma teatral considerando como marco teórico principal a Antonin Artaud y la posible vinculación con Alfred Jarry en cuanto a la ruptura de las convenciones teatrales de su época. La importancia de lo absurdo y lo grotesco como formas de reflejar la cruda condición humana, se introducen también en nuestra búsqueda de cuestionar ciertas formas y convenciones anquilosadas en nuestra sociedad, sobretodo la actual. Términos aquellos, que muchas veces se manifiestan con más credibilidad y profundidad que la lógica misma. Con ello, también se incorpora el juego entre lo ficcional y lo real/naturalista -tiempo ficcional del relato y el tiempo real en el que acontece la escena-que pone en tensión a la trama, el contenido y la forma y a la propia esencia “ubuesca”. Conceptos tales como el deseo, el poder, la ambición, la domesticación de los cuerpos, la libertad, la forma, el contenido, lo surrealista, la patafísica, etc. son términos fundamentales y de sustento para nuestro trabajo. Foucault, Calígula, Pavis, Artaud, son aquellos que posibilitan un marco para nuestros propósitos y para plasmarlos bajo nuestra plasticidad corporal y encarnación de una forma estética determinada".Adaptación libre de la trilogía Ubú de Alfred Jarry, un clásico atemporal que reflexiona sobre el poder déspota, la avaricia vil y la lujuria idiota. El Rey Padre Ubú, su mujer y un séquito de lacayos feroces, encaran un viaje por mar y tierra para asentar su trono a base de política de mentira, robo y muerte. Podría ser cualquier lugar del mundo, podría ser la Argentina de hoy y siempre.Fil: Arbach, Marcelo. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Gianola, Tomás. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Zader Rodríguez, Uriel. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Charra, Carlos Isaías Emanuel. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Ciraolo, Candela. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Muñoz, Mailén. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Piumetti, Joaquín. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Muñoz, Mailén. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina

Desmontaje de obra "Ubú forever"

La obra "Ubú forever" forma parte del Proyecto de Producción CePIAbierto 2017 (RHCD FA N° 89/2017) "Ubú y la rebelión de la forma". Adaptación libre de la trilogía Ubú de Alfred Jarry, un clásico atemporal que reflexiona sobre el poder déspota, la avaricia vil y la lujuria idiota. El hasta entonces no Rey Ubu decide que es tiempo de serlo. El pueblo festeja, no sabe bien por qué. ¿Qué más se puede hacer? Si en esta fiesta, el capricho es ley. El Rey Padre Ubú, su mujer y un séquito de lacayos feroces, encaran un viaje por mar y tierra para asentar su trono a base de política de mentira, robo y muerte. Podría ser cualquier lugar del mundo, podría ser la Argentina de hoy y siempre.El ciclo DESMONTAJE busca abrir un diálogo entre invitados especiales, creadores y público sobre los principios compositivos que presenta cada producción escénica radicada en el CePIA.Fil: Arbach, Marcelo. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Mendizábal, Lilian. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Cavo, Cristian. Universidad Provincial de Córdoba. Escuela Superior Integral de Teatro Roberto Arlt; Argentina.Fil: Gianola, Tomás. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Zader Rodríguez, Uriel. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Charra, Carlos Isaías Emanuel. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Ciraolo, Candela. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Muñoz, Mailén. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Piumetti, Joaquín. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina.Fil: Ruiz, Lautaro. Universidad Nacional de Córdoba. Facultad de Artes. Departamento de Teatro; Argentina

Surgical treatment of focal symptomatic refractory status epilepticus with and without invasive EEG

Purpose: Neurosurgery appears to be a reasonable alternative in carefully selected patients with refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE). We discuss the optimal timing of the surgery and the use of previous stereoelectroencephalography (SEEG) invasive evaluation. Methods: We identified 3 patients (two pediatric and one adult) who underwent epilepsy surgery because of RSE or SRSE from our epilepsy surgery database, one of them with previous SEEG. Results: Status epilepticus resolved acutely in all of them with no mortality and no substantial morbidity. At follow-up (median: 2 years), 1 patient was seizure-free, and 2 had significant improvement. Conclusion: Surgery should be considered in all cases of RSE and SRSE early in the course of the evolution of the disease

Dissociable Neural Information Dynamics of Perceptual Integration and Differentiation during Bistable Perception.

At any given moment, we experience a perceptual scene as a single whole and yet we may distinguish a variety of objects within it. This phenomenon instantiates two properties of conscious perception: integration and differentiation. Integration is the property of experiencing a collection of objects as a unitary percept and differentiation is the property of experiencing these objects as distinct from each other. Here, we evaluated the neural information dynamics underlying integration and differentiation of perceptual contents during bistable perception. Participants listened to a sequence of tones (auditory bistable stimuli) experienced either as a single stream (perceptual integration) or as two parallel streams (perceptual differentiation) of sounds. We computed neurophysiological indices of information integration and information differentiation with electroencephalographic and intracranial recordings. When perceptual alternations were endogenously driven, the integrated percept was associated with an increase in neural information integration and a decrease in neural differentiation across frontoparietal regions, whereas the opposite pattern was observed for the differentiated percept. However, when perception was exogenously driven by a change in the sound stream (no bistability), neural oscillatory power distinguished between percepts but information measures did not. We demonstrate that perceptual integration and differentiation can be mapped to theoretically motivated neural information signatures, suggesting a direct relationship between phenomenology and neurophysiology.This research was supported by a Wellcome Trust Biomedical Research Fellowship WT093811MA and the Chilean National Fund for Scientific and Technological Development Grant 117120